Cochrane: rigor and integrity for evidence-based data on e-cigarettes

FIVAPE Category Studies

Cochrane is an independent, international, not-for-profit organization, renowned for producing systematic reviews on health topics, including e-cigarettes. These reviews are invaluable tools for guiding public and clinical health decisions worldwide.

Cochrane’s primary goal is to produce high-quality systematic reviews. These reviews rigorously analyze all clinical Studies s on a given topic to draw reliable conclusions that can guide decisions regarding health care and public health. The organization is distinguished by its meticulous methodology, producing meta-analyses based on the best available evidence.

Visit the French Cochrane website and find their scientific reviews

Composed of researchers from more than 190 countries, the Cochrane Institute compiles and analyzes data from numerous scientific Studies to provide transparent, reliable, and unbiased conclusions. It also regularly updates its reviews to incorporate the latest research. Cochrane receives no commercial funding and has no conflicts of interest, thereby ensuring the integrity and objectivity of its work. It is supported by numerous institutions, including health organizations, nongovernmental organizations, universities, private foundations, and individual donations from around the world.

Cochrane and electronic cigarettes

The Cochrane Tobacco Addiction Group (CTAG) has played a central role in evaluating smoking cessation methods, particularly with regard to e-cigarettes. By conducting in-depth analyses, selecting Studies based on strict criteria, and relying solely on proven data, Cochrane has confirmed the effectiveness of vaping in helping people quit smoking. The Cochrane Institute thus provides crucial information for healthcare professionals and policymakers, enabling them to make informed recommendations and develop public health strategies based on the most reliable scientific data.

Studies s on Vaping: Two Major Reviews

2022 Meta-Analysis – Updated in 2025: An Effective Smoking Cessation Aid
In January 2025, a new review was conducted after incorporating two additional Studies . This review analyzed 90, Studies s involving 29,044 adult smokers. The results revealed that nicotine-containing e-cigarettes increase the likelihood of quitting smoking for at least six months, compared to other methods, including nicotine replacement therapies and nicotine-free e-cigarettes.

2023 Meta-Analysis: A Comparison of the Effectiveness of Medications and E-Cigarettes for Smoking Cessation
This review analyzed 319, Studies s involving 157,179 adult smokers and compared the effectiveness of e-cigarettes, varenicline, cytisine, and nicotine replacement therapies. The results showed that nicotine-containing e-cigarettes were one of the most effective methods for helping smokers quit.

These various reviews have demonstrated the effectiveness of vape, which is one of the top three ways to quit smoking.

Smoking cessation: nicotine vape in the top 3 most effective aids

Cochrane's findings on e-cigarettes are considered authoritative because they are based on rigorous e Studies s and a methodologically sound and transparent approach.

The Cochrane methodological process

  1. Identification of Relevant Studies : Cochrane conducts an exhaustive search of databases and clinical trial registries to identify all relevant Studies .
  2. Strict selection criteria: the Studies must meet rigorous methodological criteria, ensuring the quality of the analyzed data.
  3. Studies Quality Assessment: A thorough analysis of potential biases, sample sizes, and data collection methods is conducted to ensure the validity of the results.
  4. Statistical analysis: Cochrane uses advanced statistical methods to combine the results of different Studies s and obtain an accurate estimate of an intervention’s effect.
  5. Analysis of heterogeneity: The Institute examines the consistency of results across the Studies, to assess the impact of any differences on the conclusions.
  6. Interpretation of results: Cochrane interprets the results by taking into account bias, the quality of the Studies , and possible variations, in order to provide pragmatic and reliable recommendations.

The GRADE system: assessing the quality of evidence

Cochrane reviews are accompanied by an assessment of the level of confidence in the evidence, based on the GRADE system - Grading of Recommendations Assessment, Development and Evaluation. This system distinguishes four levels of evidence quality:

High confidence : the evidence is strong and consistent, the observed effect is reliable and unlikely to change with further research.

Moderate confidence : the evidence is strong but there are uncertainties. The observed effect is probably real, but new research could alter this assessment.

Low certainty : the evidence is unreliable, and new research could substantially alter the conclusions.

Very low certainty: the evidence is of very poor quality, the results are uncertain and the conclusions could change completely with new research.

The Cochrane opinion on electronic cigarettes

The Cochrane meta-analyses, based on rigorous methodology, confirm the effectiveness of vape compared with other smoking cessation tools.